I’ve been involved with small press publishing some years ago - in the days before print on demand, e-books, etc - that long ago!
But a friend recently self-published using the Amazon tool - I think it’s called CreateSpace - and she asked for my advice, and I did the cover design and layout for her.
She prepared her text in Word - I assisted with Styles, headers/footers, Table of contents layouts etc to make sure it was all consistent, another friend proofread - and she uploaded it into the tool without any real problem. I did the cover layout on the template they provided, using InDesign, and provided it to her as a .pdf, and again, she uploaded it herself. So from a tech point of view, pretty straightforward. They provided a very clear Guidance document which explained everything.
I was very impressed with the printed book - high quality paper, nice clean and crisp finish, proper ‘perfect binding’ and all in all much better than I had imagined for 'print on demand! My friend is delighted.
I don’t know what she paid - the only way I could get a quote was to sign up myself, which I didn’t want to do. But they did give lots of options for size, paper, full colour/cover only colour etc etc. They organised the ISBN and barcode, I just had to leave space for it to go on the cover. I would recommend an ISBN, apart from anything else it makes you look professional. There were options to publish as an e-book as well - and of course, it was all tied in to the Amazon site, instantly available. (https://www.amazon.co.uk/Wings-Fly-Poems-Uplift-Inspire/dp/1544659474/ref=sr_1_1?s=books&ie=UTF8&qid=1499691029&sr=1-1
Obviously, publishing is the easy bit - to actually sell any, you have to market like mad … but as a Folksy seller, you know that already!!